{"id":426,"date":"2019-05-01T08:00:38","date_gmt":"2019-05-01T08:00:38","guid":{"rendered":"http:\/\/darwin.eeb.uconn.edu\/uncommon-ground\/eeb348\/?p=426"},"modified":"2019-04-28T23:27:39","modified_gmt":"2019-04-28T23:27:39","slug":"rare-variants-and-genomic-prediction","status":"publish","type":"post","link":"https:\/\/darwin.eeb.uconn.edu\/uncommon-ground\/eeb348\/2019\/05\/01\/rare-variants-and-genomic-prediction\/","title":{"rendered":"Rare variants and genomic prediction"},"content":{"rendered":"<p>One thing I didn&#8217;t mention in the notes for Thursday&#8217;s lecture is that it is difficult to detect the effect of loci where one variant is rare, both because there&#8217;s a good chance you won&#8217;t have the variant in your sample (unless your sample is very large) and because it&#8217;s difficult to detect an effect when only a small number of individuals show it. The most recent <em>Nature<\/em> has a news article highlighting the challenge using our favorite polygenic trait, height in humans.<\/p>\n<p>Genetic study homes in on height\u2019s heritability mystery<\/p>\n","protected":false},"excerpt":{"rendered":"<p>One thing I didn&#8217;t mention in the notes for Thursday&#8217;s lecture is that it is difficult to detect the effect of loci where one variant is rare, both because there&#8217;s a good chance you won&#8217;t have the variant in your sample (unless your sample is very large) and because it&#8217;s difficult to detect an effect &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/darwin.eeb.uconn.edu\/uncommon-ground\/eeb348\/2019\/05\/01\/rare-variants-and-genomic-prediction\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Rare variants and genomic prediction&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-426","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/darwin.eeb.uconn.edu\/uncommon-ground\/eeb348\/wp-json\/wp\/v2\/posts\/426","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/darwin.eeb.uconn.edu\/uncommon-ground\/eeb348\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/darwin.eeb.uconn.edu\/uncommon-ground\/eeb348\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/darwin.eeb.uconn.edu\/uncommon-ground\/eeb348\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/darwin.eeb.uconn.edu\/uncommon-ground\/eeb348\/wp-json\/wp\/v2\/comments?post=426"}],"version-history":[{"count":1,"href":"https:\/\/darwin.eeb.uconn.edu\/uncommon-ground\/eeb348\/wp-json\/wp\/v2\/posts\/426\/revisions"}],"predecessor-version":[{"id":427,"href":"https:\/\/darwin.eeb.uconn.edu\/uncommon-ground\/eeb348\/wp-json\/wp\/v2\/posts\/426\/revisions\/427"}],"wp:attachment":[{"href":"https:\/\/darwin.eeb.uconn.edu\/uncommon-ground\/eeb348\/wp-json\/wp\/v2\/media?parent=426"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/darwin.eeb.uconn.edu\/uncommon-ground\/eeb348\/wp-json\/wp\/v2\/categories?post=426"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/darwin.eeb.uconn.edu\/uncommon-ground\/eeb348\/wp-json\/wp\/v2\/tags?post=426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}