Population genomics; Introduction to quantitative genetics
We will conclude our brief survey of molecular population genetics with a very brief overview of some of the additional complexities associated with analysis of high-throughput sequencing data that we haven't paid attention to. I will mention three approaches that are still widely used: RAD-seq, GBS, and low-coverage whole genome sequencinng. We won't discuss the advantages and disadvantages of the different approaches, I'll focus on two things:
- The additional insight possible because of the large amount of fine-scale data that are available.
- The additional care necessary in dealing with the data since sequencing error rates are higher.