Project 3: Natural selection in the human genome

I’ve just posted Project 3 on the course website. As with Project 2, you won’t need to analyze any data or run any simulations. Instead, you’ll need to read a paper, think about the techniques the authors used to detect natural selection (which are different from those we discussed in lecture), and answer some questions about the analysis and its implications. You can find a link to the project on the Lab Schedule page or you can follow the link below.

In other course-related news, I’ve included a YouTube video on the lecture detail page for Tuesday’s lecture. It provides a brief overview of sparg, the approach to inferring the spatial location of ancestors and the dispersal history from individual-level data. We’ll discuss sparg on Tuesday, but you may find it helpful to review the video before then.

McVicker, G., D. Gordon, and P. Green. 2009. Widespread genomic signatures of natural selection in hominid evolution. PLoS Genetics

IMPORTANT NOTE: The link to the paper was working Saturday afternoon, but it seems to be broken now (2:45pm, 7 November). The error message says this is “a likely temporary condition.” I’ll keep an eye on it. If it isn’t fixed soon, we’ll have to regroup. I also tried to get to some other papers on the PLoS Genetics website, and it appears to be affecting the whole site. The error message mentions a server configuration issue.

Update 8:05am, 8 November: I don’t know when the PLoS Genetics site came back up, but it’s up now. If you tried to get to the paper before and couldn’t, you should be able to get to it now. I’ve also downloaded a PDF that I can share if we run into trouble again.

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