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Where do $\frac{1-r}{2}$ and $\frac{r}{2}$ come from?

Consider the coupling double heterozygote, $A_1B_1/A_2B_2$. When recombination doesn't happen, $A_1B_1$ and $A_2B_2$ occur in equal frequency ($1/2$), and $A_1B_2$ and $A_2B_1$ don't occur at all. When recombination happens, the four possible gametes occur in equal frequency ($1/4$). So the recombination frequency,4 $r$, is half the crossover frequency,5 $c$, i.e., $r = c/2$. Now the results of crossing over can be expressed in this table:

Frequency $A_1B_1$ $A_1B_2$ $A_2B_1$ $A_2B_2$
$1-c$ $\frac{1}{2}$ 0 0 $\frac{1}{2}$
$c$ $\frac{1}{4}$ $\frac{1}{4}$ $\frac{1}{4}$ $\frac{1}{4}$
Total $\frac{2-c}{4}$ $\frac{c}{4}$ $\frac{c}{4}$ $\frac{2-c}{4}$
  $\frac{1-r}{2}$ $\frac{r}{2}$ $\frac{r}{2}$ $\frac{1-r}{2}$



Kent Holsinger 2008-08-19