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Maximum-likelihood estimates have a lot of nice features, but
likelihood is a slightly backwards look at the world. The likelihood
of the data is the probability of the data,
, given parameters that
we don't know,
, i.e,
. It seems a lot more natural
to think about the probability that the unknown parameter takes on
some value, given the data, i.e.,
. Surprisingly, these two
quantities are closely related. Bayes' Theorem tells us that
 |
(6) |
We refer to
as the posterior distribution of
, i.e., the probability that
takes on a particular value
given the data we've observed, and to
as the prior distribution of
, i.e., the probability that
takes on a particular value before we've looked at any
data. Notice how the relationship in (6) mimics the logic
we use to learn about the world in everyday life. We start with some
prior beliefs,
, and modify them on the basis of data
or experience,
, to reach a conclusion,
. That's the underlying logic of Bayesian
inference.14
Subsections
Next: Estimating allele frequencies with
Up: The Hardy-Weinberg Principle and
Previous: What is a maximum-likelihood
Kent Holsinger
2008-08-13