- ...
stuck,1
- Probably because he published in English and
Malécot published in French.
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- ...-statistics.2
- The Hardy-Weinberg proportions should
probably be referred to as the Hardy-Weinberg-Castle proportions too,
since Castle pointed out the same principle. For some reason, though,
his demonstration didn't have the impact that Hardy's and Weinberg's
did. So we generally talk about the Hardy-Weinberg principle.
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- ....3
- These are,
as you have probably already guessed, my personal favorite. We'll talk
about them next time.
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- ... directly.4
- See [4] for details.
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- ....5
- If
you're wondering how I got from the second equation for
to
the last one, ask me about it or read the gory details section that
follows.
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- ... details6
- Skip this part unless
you are really, really interested in how I got from the
second equation to the third equation in the last paragraph. This is
more likely to confuse you than help unless you know that the variance
of a binomial sample is
and that
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- ... taken.7
- There's
actually a third source of error that we'll get to in a moment. The
populations we're sampling from are the product of an evolutionary
process, and since the populations aren't of infinite size, drift
has played a role in determining allele frequencies in them. As a
result, if we were to go back in time and re-run the evolutionary
process, we'd end up with a different set of real allele frequency
differences. We'll talk about this more when we get to Weir and
Cockerham's statistics.
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- ....8
- There's a reason for
this that we'll get to in a moment. It's alluded to in the last
footnote.
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- ... them.9
- It
is also one big reason why most people use Weir and Cockerham's
. There's readily available software that calculates it for
you.
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- ... sampling.10
- And if you think about it carefully, I think
you'll discover that you are almost always interested in
random-effect sampling.
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- ... details11
- This is even worse
than the last time. I include it for completeness only. I really
don't expect anyone (unless they happen to be a statistician) to
be able to understand these details.
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- ... analysis.12
- Sounds like
it might be a good project, doesn't it? We'll see.
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