- ... details1
- This is even worse than the last time. I include it for completeness only. I really don't expect anyone (unless they happen to be a statistician) to be able to understand these details.
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- ...
stuck,2
- Probably because he published in English and
Malécot published in French.
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- ...-statistics.3
- The Hardy-Weinberg proportions should
probably be referred to as the Hardy-Weinberg-Castle proportions
too, since Castle pointed out the same principle. For some reason,
though, his demonstration didn't have the impact that Hardy's and
Weinberg's did. So we generally talk about the Hardy-Weinberg
principle.
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- ....4
- These are,
as you have probably already guessed, my personal favorite. We'll
talk about them next time.
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- ... data.5
- You
might also find it useful to refer to the disccusion of
-statistics in [2].
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- ... directly.6
- See [5] for details.
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- ....7
- If
you're wondering how I got from the second equation for
to
the last one, ask me about it or read the gory details section that
follows.
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- ... details8
- Skip this part unless you are
really, really interested in how I got from the second
equation to the third equation in the last paragraph. This is more
likely to confuse you than help unless you know that the variance
of a binomial sample is
and that
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- ... taken.9
- There's
actually a third source of error that we'll get to in a moment. The
populations we're sampling from are the product of an evolutionary
process, and since the populations aren't of infinite size, drift
has played a role in determining allele frequencies in them. As a
result, if we were to go back in time and re-run the evolutionary
process, we'd end up with a different set of real allele frequency
differences. We'll talk about this more when we get to Weir and
Cockerham's statistics.
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- ....10
- There's a reason for
this that we'll get to in a moment. That's only part of the reason
that
isn't used as much any more. It's not included in recent
software packages because it has some conceptual problems that we'll
get to in a moment.
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- ... sampling.11
- See Box 1
in [2] for more discussion of the difference
between statistical and evolutionary sampling.
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- ... details12
- This is even worse
than the last time. I include it for completeness only. I really
don't expect anyone (unless they happen to be a statistician) to
be able to understand these details.
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- ... analysis.13
- Sounds like
it might be a good project, doesn't it? We'll see.
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