If you're having trouble with Problem #1, you're not alone. I've spoken with many of you and shared some hints, so I thought I'd write them down and pass them along.
First, if I told you there were five alleles segregating in this population (A0, A113, A119, A123, and Au) with frequencies p0, p113, p119, p123, and pu I'll bet you could figure out how to calculate the frequency of each offspring category in this table, right?
So do that and figure out how the phenotype categories in the problem correspond to the genotype frequencies in this table. (You'll have to do this for the other maternal genotype too, obviously.)
That's the hard part, and that's the part I'm really interested in. That's biology (or at least genetics). The rest is translating the formulas you have in that table into WinBUGS.
For that, stare at the code we used for estimating allele frequencies in the ABO blood group system a bit, try your hand at a solution, and if you get stuck, stop by or e-mail Kathryn or me for some additional hints.
First, if I told you there were five alleles segregating in this population (A0, A113, A119, A123, and Au) with frequencies p0, p113, p119, p123, and pu I'll bet you could figure out how to calculate the frequency of each offspring category in this table, right?
| Maternal Genotype | Seed genotype | |||||||||
| A0A123 | A0A0 | A0A113 | A0A119 | A0A123 | A0Au | A123A0 | A123A113 | A123A119 | A123A123 | A123Au |
| ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | |
That's the hard part, and that's the part I'm really interested in. That's biology (or at least genetics). The rest is translating the formulas you have in that table into WinBUGS.
For that, stare at the code we used for estimating allele frequencies in the ABO blood group system a bit, try your hand at a solution, and if you get stuck, stop by or e-mail Kathryn or me for some additional hints.
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