Genetics of natural selection: principles

I'll say a little more about STRUCTURE to start, and I'll give a very brief overview of DAPC, but we won't spend more than another 30 minutes on population structure.

We'll devote most of today's class meeting to the genetics of natural selection, which is a very appropriate topic given that today is Darwin's Birthday. As usual, we'll illustrate the principles using one locus and two alleles. We'll also discuss only one form of natural selection, viability selection, but I'll describe what some of the other forms of natural selection are.

Viability selection at one locus with two alleles

Project #2

Online notes

Genetics of natural selection: principles

Associated readings

Chen, N., I. Juric, E. J. Cosgrove, R. Bowman, J. W. Fitzpatrick, S. J. Schoech, A. G. Clark and G. Coop. 2019. Allele frequency dynamics in a pedigreed natural population. 116:2158-2164. link

Hunter, D. and J. Slate. 2019. Understanding genetic changes between generations. 116:1834-1836. link

Rosenberg, N. A., J. K. Pritchard, J. L. Weber, H. M. Cann, K. K. Kidd, L. A. Zhivotovsky and M. W. Feldman. 2002. Genetic structure of human populations. Science 298:2381-2385. link

Wang, S., C. M. Lewis, Jr., M. Jakobsson, S. Ramachandran, N. Ray, G. Bedoya, W. Rojas, M. V. Parra, J. A. Molina, C. Gallo, G. Mazzotti, G. Poletti, K. Hill, A. M. Hurtado, D. Labuda, W. Klitz, R. Barrantes, M. C. Bortolini, F. M. Salzano, M. L. Petzl-Erler, L. T. Tsuneto, E. Llop, F. Rothhammer, L. Excoffier, M. W. Feldman, N. A. Rosenberg and A. Ruiz-Linares. 2007. Genetic Variation and Population Structure in Native Americans. PLOS Genetics 3(11): e185. link

Return to lecture schedule