Molecular evolution: patterns of nucleotide and amino acid substitution

The neutral theory of molecular evolution is clearly incomplete. We know there are differences in the rate at which proteins evolve, and we know that nucleotide substitutions occur at different rates at different codon positions. Today we'll discuss how to modify the neutral theory, keeping the compelling predictions it allows us to make while accommodating the observations that are incompatible with strict neutrality.

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Molecular evolution: patterns of nucleotide and amino acid substitution

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