Quantitative genetics: principles of association mapping

We've finished our overview of the classical approach to understanding the inheritance of quantitative traits. For the last 20 years, or so, another approach has become much more prominent. First in controlled crosses, especially controlled crosses between inbred lines, more recently in population samples, geneticists are taking advantage of the large number of molecular markers available as a result of advances in DNA sequencing technology to search for associations between molecular markers and phenotypes of interest. When successful, such analyses can reveal something close to the genotypes associated with quantitative traits, making the statistical approach we developed over the last couple of weeks somewhat less useful. There are, however, some challenges to using molecular markers in association studies. In today's lecture we will discuss both the general principles of association analysis and identify some of the pitfalls to be aware of.

Online notes

Quantitative genetics: principles of association mapping (HTML) (PDF)

Associated readings

Bush, W.S., and J.H. Moore. 2012. Chapter 11: Genome-wide association studies. PLoS Computational Biology 8:e1002822 link

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